Interventions
The interventions section is where science meets the real world. Every entry is graded on the strength of human evidence - no hype, no pseudoscience.
Sub-categories
Evidence on NMN, rapamycin, metformin, spermidine and other longevity molecules.
Caloric restriction, TRE, fasting-mimicking diets and longevity-friendly eating.
Zone 2, VO2 max, strength training and the movement stack for healthspan.
Sleep architecture, circadian rhythm, stress and recovery protocols.
Senolytics, gene and stem cell therapy, peptides, plasma exchange and HBOT.
Latest in Interventions

Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are two prominent NAD+ precursors that have gained attention for their potential role in promoting longevity. This article examines the current evidence from human trials to clarify their effects on health and aging.

Resveratrol, a compound found in red wine, has garnered attention for its potential health benefits. This article delves into the human data, mechanisms of action, and the reality behind the claims surrounding resveratrol supplementation.

Rapamycin has emerged as a leading candidate in the pursuit of longevity, showing potential to extend lifespan and improve healthspan. This article delves into its mechanisms, evidence from human studies, and safety considerations.

Spermidine, a natural polyamine, has garnered attention for its potential role in promoting autophagy and longevity. This article delves into the human observational data supporting its benefits and mechanisms of action.

GlyNAC, a combination of glycine and N-acetylcysteine, is being investigated for its potential to restore glutathione levels. This article explores the evidence from GlyNAC trials and its implications for longevity and health.

Explore the potential of GlyNAC, a combination of glycine and NAC, in restoring glutathione levels. This article delves into the GlyNAC trials, their findings, and implications for health and longevity.

Recent studies highlight taurine's potential as a key nutrient for promoting longevity. This article delves into the latest findings and their implications for health and aging.

Vitamin D and K2 are essential nutrients that play pivotal roles in maintaining bone health and cardiovascular function. This article explores their dosing guidelines, optimal blood levels, and the synergistic effects they have when taken together.

The Fasting-Mimicking Diet (FMD) developed by Valter Longo offers a novel approach to reap the benefits of fasting without complete food deprivation. This article delves into the 5-day protocol, its scientific backing, and potential health benefits.

The Fasting-Mimicking Diet (FMD), developed by Valter Longo, aims to mimic the effects of fasting while allowing for limited food intake. This evidence-based approach has emerged as a promising intervention for promoting health and longevity.

The Fasting-Mimicking Diet (FMD) developed by Valter Longo offers a unique approach to nutrition that mimics fasting while providing essential nutrients. This article delves into the science behind the FMD, its potential benefits for longevity, and the evidence supporting its use in health interventions.

The Mediterranean diet is widely recognized for its health benefits, particularly in promoting longevity. This article explores the evidence supporting this dietary pattern and its impact on life expectancy and overall health.

Exploring the relationship between protein intake, the mTOR pathway, and aging-related muscle loss. This article delves into evidence-based insights on how protein affects longevity and sarcopenia.

Blue Zones are regions where people live significantly longer than average. This article explores the commonalities and differences among these longevity hotspots, shedding light on their dietary habits and lifestyle choices.

Blue Zones are regions where people live significantly longer lives. This article explores the shared traits of these areas and highlights their unique cultural practices and dietary habits that contribute to longevity.

Fasting triggers a vital process known as autophagy, which plays a crucial role in cellular recycling. This article explores the mechanisms of autophagy during fasting, its implications for longevity, and the current evidence supporting these claims.

Zone 2 cardio is a powerful training method that enhances mitochondrial function and promotes longevity. This article explores the evidence behind its benefits and provides practical guidance for incorporating it into your fitness routine.

Exploring the critical relationship between muscle mass, strength, and longevity reveals essential insights into mortality risk. This article delves into how maintaining muscle health can significantly enhance lifespan and overall well-being.