Evidence-based longevity · No hype. No pseudoscience. Just what the data shows.
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Primary category

Interventions

The interventions section is where science meets the real world. Every entry is graded on the strength of human evidence - no hype, no pseudoscience.

Sub-categories

Supplements & Compounds

Evidence on NMN, rapamycin, metformin, spermidine and other longevity molecules.

Nutrition & Fasting

Caloric restriction, TRE, fasting-mimicking diets and longevity-friendly eating.

Exercise & Movement

Zone 2, VO2 max, strength training and the movement stack for healthspan.

Sleep & Recovery

Sleep architecture, circadian rhythm, stress and recovery protocols.

Advanced Therapies

Senolytics, gene and stem cell therapy, peptides, plasma exchange and HBOT.

Latest in Interventions

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NMN & NR
NAD+ Precursors: What NMN and NR Trials Actually Show

Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are two prominent NAD+ precursors that have gained attention for their potential role in promoting longevity. This article examines the current evidence from human trials to clarify their effects on health and aging.

Apr 11, 2026 · 7 min
Close-up of yellow transparent softgel capsules on a white background, suitable for pharmaceutical or supplement themes.
Resveratrol
Resveratrol: The Science Behind the Hype and Human Evidence

Resveratrol, a compound found in red wine, has garnered attention for its potential health benefits. This article delves into the human data, mechanisms of action, and the reality behind the claims surrounding resveratrol supplementation.

Apr 11, 2026 · 7 min
A glass bottle spilling capsules on a vivid yellow background. Perfect for healthcare and medicine themes.
Rapamycin
Rapamycin: The Most Promising Longevity Drug in Humans

Rapamycin has emerged as a leading candidate in the pursuit of longevity, showing potential to extend lifespan and improve healthspan. This article delves into its mechanisms, evidence from human studies, and safety considerations.

Apr 11, 2026 · 6 min
Top view of various herbal and pharmaceutical supplements in ceramic bowls on a green background.
Spermidine
Spermidine: A Promising Autophagy Inducer Backed by Human Studies

Spermidine, a natural polyamine, has garnered attention for its potential role in promoting autophagy and longevity. This article delves into the human observational data supporting its benefits and mechanisms of action.

Apr 11, 2026 · 7 min
A collection of assorted pills and capsules on a vibrant yellow surface.
Glycine & NAC (GlyNAC)
Glycine & NAC: A Deep Dive into GlyNAC and Glutathione Restoration

GlyNAC, a combination of glycine and N-acetylcysteine, is being investigated for its potential to restore glutathione levels. This article explores the evidence from GlyNAC trials and its implications for longevity and health.

Apr 11, 2026 · 8 min
A close-up image of various pills and capsules showcasing diverse colors and types of pharmaceuticals.
Glycine & NAC (GlyNAC)
Glycine and NAC: A Comprehensive Look at GlyNAC Trials for Glutathione Restoration

Explore the potential of GlyNAC, a combination of glycine and NAC, in restoring glutathione levels. This article delves into the GlyNAC trials, their findings, and implications for health and longevity.

Apr 11, 2026 · 7 min
Top view of various herbal and pharmaceutical supplements in ceramic bowls on a green background.
Taurine
Taurine: A Promising Longevity Nutrient Unveiled by 2023 Science

Recent studies highlight taurine's potential as a key nutrient for promoting longevity. This article delves into the latest findings and their implications for health and aging.

Apr 11, 2026 · 7 min
Close-up of open glass jar filled with yellow health capsules on light surface.
Vitamin D & K2
Optimizing Vitamin D and K2: Dosing, Blood Levels, and Synergy

Vitamin D and K2 are essential nutrients that play pivotal roles in maintaining bone health and cardiovascular function. This article explores their dosing guidelines, optimal blood levels, and the synergistic effects they have when taken together.

Apr 11, 2026 · 5 min
People gathered around a table praying before an iftar dinner during Ramadan, showcasing cultural and religious practices.
Fasting-Mimicking Diet
Exploring the Fasting-Mimicking Diet: Insights from Valter Longo's Protocol

The Fasting-Mimicking Diet (FMD) developed by Valter Longo offers a novel approach to reap the benefits of fasting without complete food deprivation. This article delves into the 5-day protocol, its scientific backing, and potential health benefits.

Apr 11, 2026 · 7 min
A floral plate with a fork and blue measuring tape symbolizing dieting or healthy eating.
Fasting-Mimicking Diet
Exploring the Fasting-Mimicking Diet: A 5-Day Protocol for Longevity

The Fasting-Mimicking Diet (FMD), developed by Valter Longo, aims to mimic the effects of fasting while allowing for limited food intake. This evidence-based approach has emerged as a promising intervention for promoting health and longevity.

Apr 11, 2026 · 7 min
Flat lay of nuts, grains, and beans artfully arranged on a marble countertop.
Fasting-Mimicking Diet
Exploring the Fasting-Mimicking Diet: Insights from Valter Longo's Protocol

The Fasting-Mimicking Diet (FMD) developed by Valter Longo offers a unique approach to nutrition that mimics fasting while providing essential nutrients. This article delves into the science behind the FMD, its potential benefits for longevity, and the evidence supporting its use in health interventions.

Apr 11, 2026 · 7 min
A colorful Mediterranean salad featuring feta, olives, chickpeas, and fresh greens.
Mediterranean Diet
The Mediterranean Diet: A Proven Path to Longevity

The Mediterranean diet is widely recognized for its health benefits, particularly in promoting longevity. This article explores the evidence supporting this dietary pattern and its impact on life expectancy and overall health.

Apr 11, 2026 · 7 min
Assorted mixed nuts spill from a glass jar on a light surface, highlighting a variety of textures and colors.
Protein & Aging
The Protein-Aging Debate: mTOR, Sarcopenia, and Longevity

Exploring the relationship between protein intake, the mTOR pathway, and aging-related muscle loss. This article delves into evidence-based insights on how protein affects longevity and sarcopenia.

Apr 11, 2026 · 6 min
Elderly Asian woman in a blue top enjoys a meal indoors, showcasing cultural dining practices.
Blue Zones
Unveiling the Secrets of Blue Zones: What Centenarians Share and Don't

Blue Zones are regions where people live significantly longer than average. This article explores the commonalities and differences among these longevity hotspots, shedding light on their dietary habits and lifestyle choices.

Apr 11, 2026 · 8 min
A nutritious berry smoothie bowl topped with chia seeds, blackberries, blueberries, and coconut flakes.
Blue Zones
Exploring Blue Zones: Common Traits of Centenarian Hotspots

Blue Zones are regions where people live significantly longer lives. This article explores the shared traits of these areas and highlights their unique cultural practices and dietary habits that contribute to longevity.

Apr 11, 2026 · 5 min
Top view of composed raw almond with seeds and avocado on table with berries on scales for cooking healthy dish
Autophagy & Fasting
Understanding Fasting: The Science of Cellular Recycling Through Autophagy

Fasting triggers a vital process known as autophagy, which plays a crucial role in cellular recycling. This article explores the mechanisms of autophagy during fasting, its implications for longevity, and the current evidence supporting these claims.

Apr 11, 2026 · 8 min
Two people jogging outdoors on a sunny day, emphasizing fitness and healthy lifestyle.
Zone 2 Cardio
Unlocking Longevity: The Science of Zone 2 Cardio

Zone 2 cardio is a powerful training method that enhances mitochondrial function and promotes longevity. This article explores the evidence behind its benefits and provides practical guidance for incorporating it into your fitness routine.

Apr 11, 2026 · 6 min
A senior man with a beard exercises shirtless outdoors with dumbbells, emphasizing fitness and determination.
Strength Training for Longevity
Muscle Mass and Strength: Key Predictors of Longevity

Exploring the critical relationship between muscle mass, strength, and longevity reveals essential insights into mortality risk. This article delves into how maintaining muscle health can significantly enhance lifespan and overall well-being.

Apr 11, 2026 · 7 min

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