Science
Science is the foundation of everything we publish. This section covers the molecular, cellular and systems-level biology of aging, the major diseases that kill us as we get older, the biomarkers researchers use to measure biological age, and the labs and institutes driving the field forward.
Sub-categories
Evidence on NMN, rapamycin, metformin, spermidine and other longevity molecules.
Caloric restriction, TRE, fasting-mimicking diets and longevity-friendly eating.
Zone 2, VO2 max, strength training and the movement stack for healthspan.
Sleep architecture, circadian rhythm, stress and recovery protocols.
Senolytics, gene and stem cell therapy, peptides, plasma exchange and HBOT.
Latest in Science
The hallmarks of aging proposed by López-Otín and colleagues serve as a comprehensive framework for understanding the biological processes that contribute to aging. This article explores each hallmark, its implications for longevity research, and the current evidence supporting these concepts.
Cellular senescence plays a crucial role in aging and age-related diseases. This article explores the mechanisms behind senescent cells, their impact on health through the senescence-associated secretory phenotype (SASP), and the potential of senolytics as a therapeutic strategy.
Mitochondrial dysfunction is a key factor in the aging process, influencing cellular energy production and health. This article explores the decline of mitochondria, the role of mitophagy, and the importance of NAD+ in promoting longevity.
Mitochondrial dysfunction plays a pivotal role in the aging process, impacting cellular energy production and overall health. This article explores the mechanisms of mitochondrial decline, the importance of mitophagy, and the role of NAD+ in promoting longevity.
Epigenetic clocks are powerful tools that measure biological aging through DNA methylation patterns. This article explores the most prominent clocks, including Horvath, PhenoAge, and GrimAge, and their implications for understanding aging biology.
This article explores the critical roles of proteostasis and autophagy in maintaining cellular health and their implications for aging and longevity. We examine current research and evidence linking these processes to age-related diseases and potential interventions for promoting healthy aging.
Atherosclerosis is a leading cause of cardiovascular disease, significantly contributing to mortality worldwide. This article delves into the role of apolipoprotein B (ApoB) in atherosclerosis and its implications for public health.
Insulin resistance and metabolic syndrome have significant implications for longevity and overall health. This article explores the evidence linking these conditions to aging and offers insights into potential interventions for better health outcomes.
Osteoporosis is a significant health concern, particularly in aging populations, leading to increased fracture risk. This article explores the relationship between bone density, fracture risk, and the role of mechanical loading in maintaining bone health.
Osteoporosis is a significant concern for aging populations, characterized by reduced bone density and increased fracture risk. This article explores the mechanisms behind osteoporosis, highlighting the importance of bone loading and preventative measures to maintain skeletal health.
High-sensitivity C-reactive protein (hs-CRP) serves as a crucial biomarker for assessing chronic inflammation, which is increasingly recognized as a significant factor in longevity. This article explores the relationship between hs-CRP levels, inflammation, and their implications for health and lifespan.
Explore the groundbreaking work of leading university labs focused on longevity, including the research of David Sinclair, Matt Kaeberlein, and others. Discover how their innovative approaches are shaping our understanding of aging and potential interventions.
An evidence-based look at The 12 hallmarks of aging, explained in plain English as part of our Hallmarks of Aging guide in Aging Biology. What the human research actually shows, the strongest mechanistic case, and what it means for healthspan.
An evidence-based look at From 9 to 12: how the hallmarks framework was updated in 2023 as part of our Hallmarks of Aging guide in Aging Biology. What the human research actually shows, the strongest mechanistic case, and what it means for healthspan.
An evidence-based look at Which hallmarks of aging matter most for humans as part of our Hallmarks of Aging guide in Aging Biology. What the human research actually shows, the strongest mechanistic case, and what it means for healthspan.
An evidence-based look at How the hallmarks framework shaped the last decade of longevity research as part of our Hallmarks of Aging guide in Aging Biology. What the human research actually shows, the strongest mechanistic case, and what it means for healthspan.
An evidence-based look at What are senescent cells and why do they matter as part of our Cellular Senescence guide in Aging Biology. What the human research actually shows, the strongest mechanistic case, and what it means for healthspan.
An evidence-based look at The senescence-associated secretory phenotype (SASP), explained as part of our Cellular Senescence guide in Aging Biology. What the human research actually shows, the strongest mechanistic case, and what it means for healthspan.